The role of the Bcl-2 family in the regulation of outer mitochondrial membrane permeability

@article{Harris2000TheRO,
  title={The role of the Bcl-2 family in the regulation of outer mitochondrial membrane permeability},
  author={Marian H. Harris and Craig B Thompson},
  journal={Cell Death and Differentiation},
  year={2000},
  volume={7},
  pages={1182-1191}
}
Mitochondria are well known as sites of electron transport and generators of cellular ATP. Mitochondria also appear to be sites of cell survival regulation. In the process of programmed cell death, mediators of apoptosis can be released from mitochondria through disruptions in the outer mitochondrial membrane; these mediators then participate in the activation of caspases and of DNA degradation. Thus the regulation of outer mitochondrial membrane integrity is an important control point for… CONTINUE READING

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Bcl-xL prevents the initial decrease in mitochondrial membrane potential and subsequent reactive oxygen species production during tumor necrosis factor alpha-induced apoptosis

  • E Gottlieb, M Vander Heiden, C Thompson
  • Mol. Cell. Biol
  • 2000

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