The role of the APC tumor suppressor in chromosomal instability.

  title={The role of the APC tumor suppressor in chromosomal instability.},
  author={Paola Alberici and Riccardo Fodde},
  journal={Genome dynamics},
Colorectal cancer (CRC) still represents the model of choice to study the mechanisms underlying tumor initiation and progression. Accordingly, CRC has been central in the analysis of the role played by chromosomal instability (CIN) in tumor initiation and progression. Although loss of APC tumor suppressor function initiates the adenoma-carcinoma sequence in the vast majority of CRCs through constitutive activation of Wnt/beta-catenin signaling, the APC gene also represents a candidate CIN gene… CONTINUE READING


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