The role of the AMP-activated protein kinase in the regulation of energy homeostasis.

@article{Carling2007TheRO,
  title={The role of the AMP-activated protein kinase in the regulation of energy homeostasis.},
  author={David Carling},
  journal={Novartis Foundation symposium},
  year={2007},
  volume={286},
  pages={72-81; discussion 81-5, 162-3, 196-203}
}
AMP-activated protein kinase (AMPK) is the downstream component of a protein kinase cascade that plays a major role in maintaining energy homeostasis. Within individual cells, AMPK is activated by a rise in the AMP:ATP ratio that occurs following a fall in ATP levels. AMPK is also regulated by the adipokines, adiponectin and leptin, hormones that are secreted from adipocytes. Activation of AMPK requires phosphorylation of threonine 172 within the catalytic subunit by either LKB1 or calcium… CONTINUE READING