The role of the ACTH receptor in adrenal tumors: identification of a novel microsatellite marker.

@article{Zwermann2004TheRO,
  title={The role of the ACTH receptor in adrenal tumors: identification of a novel microsatellite marker.},
  author={Oliver Zwermann and Felix Beuschlein and Albrecht Klink and M. R. Stahl and Martin Reincke},
  journal={Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme},
  year={2004},
  volume={36 6},
  pages={406-10}
}
In vitro, the growth inhibiting effect of ACTH on adrenocortical cells is well documented, even though there are reports of opposite effects under defined cell culture conditions. In vivo, activation of the ACTH receptor (ACTHR) has a trophic effect on the adrenal cortex, while the effects on proliferation are still under discussion, especially since other POMC derived peptides have been characterized. However, ACTH is thought to act as a differentiation factor with inhibiting effects on tumor… CONTINUE READING