The role of tetramerization in p53 function

@article{Chne2001TheRO,
  title={The role of tetramerization in p53 function},
  author={Patrick Ch{\`e}ne},
  journal={Oncogene},
  year={2001},
  volume={20},
  pages={2611-2617}
}
The tumour suppressor gene p53 is extensively studied for its importance in cancer. In its active conformation, p53 is tetrameric and one domain – the tetramerization domain – permits the oligomerization of this protein. Until recently, little attention was given to this domain because, in contrast to the DNA-binding domain, it is not often mutated in cancer. However, various experimental studies have shown evidence that the tetramerization domain is essential for DNA binding, protein–protein… CONTINUE READING

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Showing 1-10 of 18 references

Histol

  • ML Hixon, A Flores, M Wagner, A. Gualberto
  • Histopathol., 15, 551 ± 556.
  • 2000
2 Excerpts

Hum

  • T Soussi, K Dehouche, C. Beroud
  • Mutat., 15, 105 ± 113.
  • 2000
3 Excerpts

J

  • S Strano, E Munarriz, +8 authors G. Blandino
  • Biol. Chem., 275, 29503 ± 29512.
  • 2000

Pathol

  • E Appella, Anderson CW.
  • Biol. (Paris),
  • 2000

Biol

  • K. Roemer
  • Chem., 380, 879 ± 887.
  • 1999
2 Excerpts

Cell

  • M Oren, V. Rotter
  • Mol. Life Sci., 55, 9 ± 11.
  • 1999
2 Excerpts

Mutat

  • M Hollstein, M Hergenhahn, Q Yang, H Bartsch, ZQ Wang, P. Hainaut
  • Res., 431, 199 ± 209.
  • 1999
2 Excerpts

Nat

  • MG Mateu, MM Sanchez Del Pino, AR. Fersht
  • Struct. Biol., 6, 191 ± 198.
  • 1999

Acta Crystallogr

  • PR Mittl, P CheÁ ne, MG. Grutter
  • D. Biol. Crystallogr., 54, 86 ± 89.
  • 1998
2 Excerpts

Br

  • RJ Steele, AM Thompson, PA Hall, DP. Lane
  • J. Surg., 85, 1460 ± 1467.
  • 1998
2 Excerpts

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