The role of testosterone in the metabolic syndrome: A review

  title={The role of testosterone in the metabolic syndrome: A review},
  author={Farid Saad and Louis J Gooren},
  journal={The Journal of Steroid Biochemistry and Molecular Biology},
  • F. SaadL. Gooren
  • Published 1 March 2009
  • Medicine, Biology
  • The Journal of Steroid Biochemistry and Molecular Biology

The role of testosterone in type 2 diabetes and metabolic syndrome in men.

  • F. Saad
  • Medicine, Biology
    Arquivos brasileiros de endocrinologia e metabologia
  • 2009
Testosterone treatment reverses part of the unfavorable risk profile for the development of diabetes and atherosclerosis, and if diabetes mellitus is viewed in the context of the metabolic syndrome, the present results of testosterone treatment are very encouraging.

The Role of Testosterone in the Etiology and Treatment of Obesity, the Metabolic Syndrome, and Diabetes Mellitus Type 2

Testosterone plays a significant role in obesity, glucose homeostasis, and lipid metabolism, and Administration of testosterone to hypogonadal men reverses part of the unfavorable risk profile for the development of diabetes and atherosclerosis.

Role of testosterone and cortisol in metabolic syndrome and type 2 diabetes mellitus

It is suggested that low levels of testosterone could predispose to abdominal obesity provoking an alteration of fat acid metabolism, which at the same time will promote the insulin resistance.

Roles of Testosterone in Men with Type 2 Diabetes: A Review

The objective of this paper is reviewing the roles of testosterone in men with type 2 diabetes and finding improvements in glycaemic control, insulin resistance, cholesterol and visceral adiposity together represent an overall reduction in cardiovascular risk.

ADT and the metabolic syndrome: no good deed goes unpunished.

  • J. Pinthus
  • Medicine, Biology
    Canadian Urological Association journal = Journal de l'Association des urologues du Canada
  • 2011
It is demonstrated that 1 year of ADT use is associated with elevated fasting glucose levels and this data is in line with a recent review of the ADT/metabolic syndrome which showed a clear casual association between ADT and diabetes mellitus, but the causal association is not as strong with CVS morbidity.

The effect of testosterone on factors associated with diabetes, atherosclerosis and obesity.

Although testosterone therapy showed a positive effect on some risk factors of obesity and its associated conditions, negative effects were also seen and further studies are needed to fully elucidate the above finding.

Association between testosterone levels, insulin sensitivity, adiposity and lipid parameters in men

A direct relationship was found between testosterone levels and insulin sensitivity in the population studied and the need for an early metabolic assessment of patients with hypogonadism is suggested.

Are Androgens Valuable in Management of Diabetes

It is established, that the testosterone deficiency promotes the development of the metabolic syndrome, insulin resistance, type 2 diabetes mellitus, hyperglycemia, as well as dyslipidemia and

Androgens and male aging: Current evidence of safety and efficacy.

  • L. Gooren
  • Medicine
    Asian journal of andrology
  • 2010
The pivotal question whether the age-related decline of testosterone must be viewed as hypogonadism, in the best case reversed by testosterone treatment, has not been definitively resolved and as yet there is no definitive proof of the beneficial effects of restoring testosterone levels to normal in elderly men on clinical parameters.

Baseline Data from the TRiUS Registry: Symptoms and Comorbidities of Testosterone Deficiency

Untreated hypogonadal middle-aged men exhibited a high prevalence of cardiometabolic risk factors that were correlated to TT levels, which suggests that TD is associated with adverse medical conditions that pose serious health risks, especially in a younger age demographic than previously thought.



Androgen deficiency, diabetes, and the metabolic syndrome in men

  • R. KalyaniA. Dobs
  • Medicine, Biology
    Current opinion in endocrinology, diabetes, and obesity
  • 2007
Testosterone supplementation, by either oral or intramuscular routes and through exogenous or endogenous delivery, has a promising role in this population although further clinical trials are needed.

Sex hormones, inflammation and the metabolic syndrome: a population-based study.

Even in the absence of late-stage consequences such as diabetes and cardiovascular disease, subtle derangements in sex hormones are present in the metabolic syndrome, and may contribute to its pathogenesis.

Testosterone and sex hormone-binding globulin predict the metabolic syndrome and diabetes in middle-aged men.

Low total testosterone and SHBG levels independently predict development of the metabolic syndrome and diabetes in middle-aged men, and hypoandrogenism is an early marker for disturbances in insulin and glucose metabolism that may progress to the metabolic Syndrome or frank diabetes and may contribute to their pathogenesis.

Low sex hormone-binding globulin, total testosterone, and symptomatic androgen deficiency are associated with development of the metabolic syndrome in nonobese men.

Low serum SHBG, low total testosterone, and clinical AD are associated with increased risk of developing MetS over time, particularly in nonoverweight, middle-aged men (BMI, <25).

The effects of induced hypogonadism on arterial stiffness, body composition, and metabolic parameters in males with prostate cancer.

The data indicate that induced hypogonadism in males with prostate cancer results in a rise in the augmentation of central arterial pressure, suggesting large artery stiffening.

Endogenous sex hormones and metabolic syndrome in aging men.

Higher testosterone and SHBG levels in aging males are independently associated with a higher insulin sensitivity and a reduced risk of the metabolic syndrome, independent of insulin levels and body composition measurements, suggesting that these hormones may protect against the development of metabolic syndrome.

Aging, androgens, and the metabolic syndrome in a longitudinal study of aging.

The prevalence of the metabolic syndrome increased with aging, and this was associated with lower androgen levels, and lower total T and SHBG predicted a higher incidence of the MS.

Increasing insulin resistance is associated with a decrease in Leydig cell testosterone secretion in men.

It is concluded that insulin resistance is associated with a decrease in Leydig cell T secretion in men with a spectrum of insulin sensitivity.