The role of teratogens in neural crest development

  title={The role of teratogens in neural crest development},
  author={Santiago Cerrizuela and Guillermo A Vega-L{\'o}pez and Manuel J. Aybar},
  journal={Birth Defects Research},
  pages={584 - 632}
The neural crest (NC), discovered by Wilhelm His 150 years ago, gives rise to a multipotent migratory embryonic cell population that generates a remarkably diverse and important array of cell types during the development of the vertebrate embryo. These cells originate in the neural plate border (NPB), which is the ectoderm between the neural plate and the epidermis. They give rise to the neurons and glia of the peripheral nervous system, melanocytes, chondrocytes, smooth muscle cells… 

Neurogenesis From Neural Crest Cells: Molecular Mechanisms in the Formation of Cranial Nerves and Ganglia

The role of cell signaling and of the function of transcription factors involved in the specification of ganglia precursors and neurogenesis to form the NC-derived cranial nerves during organogenesis are given.

Neuro-mesodermal assembloids recapitulate aspects of peripheral nervous system development in vitro

Here we describe a novel neuro-mesodermal assembloid model which recapitulates aspects of peripheral nervous system (PNS) development such as neural crest cell (NCC) induction, delamination,

Insights into vertebrate head development: from cranial neural crest to the modelling of neurocristopathies.

The contributions from the laboratory reveal that proper zebrafish head development depends on the fine-tuning of developmental-gene expression mediated by nucleic acid binding proteins able to regulate the DNA conformation and / or neuroepithelium redox state.

Treatment and Prevention of Neurocristopathies.

  • N. Pilon
  • Medicine
    Trends in molecular medicine
  • 2021

Gastruloids: A Novel System for Disease Modelling and Drug Testing.

This review summarises the recent developments in the use of gastruloids to model congenital anomalies, their usage in teratogenicity testing, and the current limitations of this emerging field.


The proposed RP-HPLC method has been found to be fast, simple, feasible and affordable in assay condition and can be used for routine analysis of the selected drugs during stability tests.



Tumors of the neural crest: Common themes in development and cancer

This review focuses on tumors that arise from NC‐derived tissues and examines mechanistic themes shared during their oncogenic and metastatic development with embryonic NC cell ontogeny.

Specifying neural crest cells: From chromatin to morphogens and factors in between

  • C. RogersS. Nie
  • Biology
    Wiley interdisciplinary reviews. Developmental biology
  • 2018
The mechanisms required for the induction and specification of NC cells in various vertebrate species are discussed, focusing on the roles of early morphogenesis, cell adhesion, signaling from adjacent tissues, and the massive transcriptional network that controls the formation of these amazing cells.

Neural crest derivatives in ocular development: discerning the eye of the storm.

The role of ocular NCCs in eye development is summarized, particularly focusing on congenital eye diseases associated with anterior segment defects and the interplay between three prominent molecules, PITX2, CYP1B1, and retinoic acid, which act in concert to specify a population of neural crest-derived mesenchymal progenitors for migration and differentiation, to give rise to distinct anterior segment tissues.

Respective contribution of the cephalic neural crest and mesoderm to SIX1-expressing head territories in the avian embryo

A dynamic tissue-specific expression of SIX1 in a variety of cephalic NC- and mesoderm-derived cell types and tissues is pointed to, opening the way for further analysis of Six1 function in the coordinated development of these two cellular populations during vertebrate head formation.

Neural crest stem cells and their potential therapeutic applications.

microRNAs associated with early neural crest development in Xenopus laevis

Novel tissue specific miRNAs are identified in Xenopus embryonic explants treated to form ectoderm, neural or NC tissue and differential expression of miR-427 isoforms are highlighted.

Human Pluripotent Stem Cell-Derived Neural Crest Cells for Tissue Regeneration and Disease Modeling

The various in vitro strategies that have been used to derive N CCs from hPSCs and to specify NCCs into cranial, trunk, and vagal subpopulations and their derivatives are reviewed.