The role of tenascin C in cardiovascular disease.

  title={The role of tenascin C in cardiovascular disease.},
  author={Jonathan Golledge and Paula Clancy and Jane Margaret Maguire and Lisa F Lincz and Simon Andrea Koblar},
  journal={Cardiovascular research},
  volume={92 1},
The extracellular matrix protein tenascin C (TnC) is expressed in a variety of embryonic tissues, but its expression in adult arteries is co-incident with sites of vascular disease. TnC expression has been linked to the development and complications of intimal hyperplasia, pulmonary artery hypertension, atherosclerosis, myocardial infarction, and heart failure. This review identifies the growing collection of evidence linking TnC with cardiovascular disease development. The transient… CONTINUE READING