The role of template-primer interactions in cleavage and initiation by the influenza virus polymerase.

Abstract

An in vitro cleavage/initiation assay was used to analyse cleavage site choice and transcription initiation by the influenza virus polymerase. A synthetic mRNA which is cleaved by the polymerase to produce a single 11 base primer fragment was altered around this cleavage site. Depending upon the mutations made, alternative cleavage sites were used. This… (More)

Topics

Cite this paper

@article{Hagen1995TheRO, title={The role of template-primer interactions in cleavage and initiation by the influenza virus polymerase.}, author={Mary E. Hagen and Laurence S. Tiley and Thomas D Y Chung and Mark R Krystal}, journal={The Journal of general virology}, year={1995}, volume={76 ( Pt 3)}, pages={603-11} }