The role of temperature in the action of local anesthetics: a double study in vitro and in vivo.

@article{Dabarakis2006TheRO,
  title={The role of temperature in the action of local anesthetics: a double study in vitro and in vivo.},
  author={Nikolaos Nestoras Dabarakis and Anastasios T. Tsirlis and Nikolaos A Parisis},
  journal={The International journal of neuroscience},
  year={2006},
  volume={116 1},
  pages={67-75}
}
The purpose of this study was the examination of the role of temperature in the action of lidocaine via electrophysiological recordings on the sciatic nerve of the rat in vitro and in vivo. 20 Male Wistar rats were used in each type of experiment. In vitro, lidocaine shows no statistically significant difference regarding the onset of anesthesia but at the temperature of 25 degrees C it is significantly more potent on the establishment of anesthesia compared to the temperature of 36.5 degrees C… CONTINUE READING

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