The role of telocytes in morphogenetic bioelectrical signaling: once more unto the breach

@article{Edelstein2014TheRO,
  title={The role of telocytes in morphogenetic bioelectrical signaling: once more unto the breach},
  author={Lawrence Edelstein and John Smythies},
  journal={Frontiers in Molecular Neuroscience},
  year={2014},
  volume={7}
}
This paper explores the possibility that telocytes play a major role in morphogenetic bioelectrical signaling. 
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References

SHOWING 1-10 OF 35 REFERENCES
Transducing Bioelectric Signals into Epigenetic Pathways During Tadpole Tail Regeneration
TLDR
A technique for convenient alteration of transmembrane potential in vivo that does not require transgenes is presented, and new data in the Xenopus tail is presented consistent with the hypothesis that the monocarboxlyate transporter SLC5A8 may link regeneration‐relevant epigenetic modification with upstream changes in ion content.
Bioelectric mechanisms in regeneration: Unique aspects and future perspectives.
  • M. Levin
  • Biology
    Seminars in cell & developmental biology
  • 2009
Human myometrium – the ultrastructural 3D network of telocytes
TLDR
The presence of extracellular vesicles (shedding vesicle/exosomes) along the Tps suggests an active intercellular signalling (micro‐ and macromolecules), with possible significance in regulating uterine contractility.
Endogenous voltage gradients as mediators of cell-cell communication: strategies for investigating bioelectrical signals during pattern formation
TLDR
The dissection of bioelectric events as instructive signals enabling the orchestration of cell behaviors into large-scale coherent patterning programs will enrich on-going work in diverse areas of biology, as biophysical factors become incorporated into the authors' systems-level understanding of cell interactions.
Molecular bioelectricity in developmental biology: New tools and recent discoveries
  • M. Levin
  • Biology
    BioEssays : news and reviews in molecular, cellular and developmental biology
  • 2012
TLDR
Transmembrane voltage gradients determine anatomical polarity and function as master regulators during appendage regeneration and embryonic left‐right patterning and can also serve as prepatterns for gene expression domains during craniofacial patterning.
Cardiac Telocytes.
TLDR
Recent progress on the potential biological function of stromal cells in cardiac physiology and disease is summarized.
Epigenetic aspects of telocytes/cordocytes: jacks of all trades, masters of most
TLDR
It is proposed that T/Cs are capable of forming an extensive intercellular information transmission and executive system that may utilize electric currents, small molecules, exosomes and possibly electrical events within the cytoskeleton—to modulate homeostasis, stem cell activity, tissue repair, peristalsis, anticancer activity, and other complex functions in many organs.
Identification of telocytes in skeletal muscle interstitium: implication for muscle regeneration
TLDR
In culture, TCs (but not satellite cells) emerge from muscle explants and form networks suggesting a key role in muscle regeneration and repair, at least after trauma.
Telocytes, exosomes, gap junctions and the cytoskeleton: the makings of a primitive nervous system?
TLDR
Telocytes form a dense convoluted network linking TCs with each other, and with many other cell types including secretory acini and exocrine epithelial ducts, nerve fibers, macrophages, and blood vessels, which suggests that TCs are involved in integrating neural, vascular and endocrine processes.
...
...