The role of tau phosphorylation and cleavage in neuronal cell death.

@article{Chun2007TheRO,
  title={The role of tau phosphorylation and cleavage in neuronal cell death.},
  author={W. Chun and G. Johnson},
  journal={Frontiers in bioscience : a journal and virtual library},
  year={2007},
  volume={12},
  pages={
          733-56
        }
}
  • W. Chun, G. Johnson
  • Published 2007
  • Biology, Medicine
  • Frontiers in bioscience : a journal and virtual library
The microtubule-associated protein tau is the primary component of the intracellular filamentous deposits found in Alzheimer's disease (AD) brain and also in a family of neurodegenerative diseases called 'tauopathies', where tau pathology is the primary, defining characteristic with little or no amyloid-beta (Abeta) pathology. It has been demonstrated that tau modifications such as hyperphosphorylation and truncation might be important events in the process leading to tau intracellular… Expand
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