The role of tau in the pathological process and clinical expression of Huntington’s disease

@inproceedings{Vuono2015TheRO,
  title={The role of tau in the pathological process and clinical expression of Huntington’s disease},
  author={Romina Vuono and Sophie E. Winder-Rhodes and R. Erandie Ediriweera De Silva and Giulia Cisbani and Janelle Drouin-Ouellet and Maria Grazia Spillantini and Francesca Cicchetti and Roger A. Barker},
  booktitle={Brain : a journal of neurology},
  year={2015}
}
Huntington's disease is a neurodegenerative disorder caused by an abnormal CAG repeat expansion within exon 1 of the huntingtin gene HTT. While several genetic modifiers, distinct from the Huntington's disease locus itself, have been identified as being linked to the clinical expression and progression of Huntington's disease, the exact molecular mechanisms driving its pathogenic cascade and clinical features, especially the dementia, are not fully understood. Recently the microtubule… CONTINUE READING
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