The role of synovitis in pathophysiology and clinical symptoms of osteoarthritis

  title={The role of synovitis in pathophysiology and clinical symptoms of osteoarthritis},
  author={J{\'e}r{\'e}mie Sellam and Francis Berenbaum},
  journal={Nature Reviews Rheumatology},
Osteoarthritis (OA), one of the most common rheumatic disorders, is characterized by cartilage breakdown and by synovial inflammation that is directly linked to clinical symptoms such as joint swelling, synovitis and inflammatory pain. The gold-standard method for detecting synovitis is histological analysis of samples obtained by biopsy, but the noninvasive imaging techniques MRI and ultrasonography might also perform well. The inflammation of the synovial membrane that occurs in both the… CONTINUE READING
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