The role of synovial macrophages and macrophage-produced mediators in driving inflammatory and destructive responses in osteoarthritis.

@article{Bondeson2010TheRO,
  title={The role of synovial macrophages and macrophage-produced mediators in driving inflammatory and destructive responses in osteoarthritis.},
  author={Jan Bondeson and A. B. Holthuysen Blom and Shane D Wainwright and Clare Hughes and Bruce Caterson and Wim B. van den Berg},
  journal={Arthritis and rheumatism},
  year={2010},
  volume={62 3},
  pages={647-57}
}
Osteoarthritis (OA), one of the most common diseases among humans, is characterised pathologically by focal areas of damage on articular cartilage centred on load-bearing areas, associated with formation of new bone at the joint margins and changes in subchondral bone. Given the huge economic and personal burden of OA, and the fact that this disease is the major cause for the increasing demand for joint replacements, there is urgent need for disease modifying treatments to stop or at least slow… CONTINUE READING

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  • Jan Bondeson, Shane Wainwright, Clare Hughes, Bruce Caterson
  • 2012

The role of synovial macrophages and macrophage-produced mediators in driving inflammatory and destructive responses in osteoarthritis

  • J. Bondeson, A. B. Blom, S. Wainwright, C. Hughes, B. Caterson, W. B. van den Berg
  • Arthritis and Rheumatism
  • 2010
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