The role of superoxide anion generation in phagocytic bactericidal activity. Studies with normal and chronic granulomatous disease leukocytes.

@article{Johnston1975TheRO,
  title={The role of superoxide anion generation in phagocytic bactericidal activity. Studies with normal and chronic granulomatous disease leukocytes.},
  author={R. Johnston and B. B. Keele and H. Misra and J. Lehmeyer and L. Webb and R. Baehner and K. Rajagopalan},
  journal={The Journal of clinical investigation},
  year={1975},
  volume={55 6},
  pages={
          1357-72
        }
}
The capacity of human phagocytes to generate superoxide anion (O2-), a free radical of oxygen, and a possible role for this radical or its derivatives in the killing of phagocytized bacteria were explored using leukocytes from normal individuals and patients with chronic granulomatous disease (CGD). Superoxide dismutase, which removes O2-, consistently inhibited phagocytosis-associated nitroblue tetrazolium (NBT) reduction indicating the involvement of O2- in this process. Similarly, superoxide… Expand
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