The role of superoxide and hydroperoxide in the reductive activation of tryptophan-2,3-dioxygenase.

Abstract

Activation of aerobically aged rat liver and Pseudomonas acidouorans tryptophan-2,3-dioxygenase (EC 1.13.1.12) by reducing agents was studied in an attempt to define the chemical nature of the species which achieves the reduction. With the use of two enzymes, superoxide dismutase and catalase, reductive activation by sodium ascorbate, sodium borohydride… (More)

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