The role of subunit composition on prepulse facilitation of the cardiac L-type calcium channel.

@article{Dai1999TheRO,
  title={The role of subunit composition on prepulse facilitation of the cardiac L-type calcium channel.},
  author={Sun Fang Dai and Norbert Klugbauer and Xiangang Zong and Claudia Seisenberger and Franz Hofmann},
  journal={FEBS letters},
  year={1999},
  volume={442 1},
  pages={
          70-4
        }
}
Facilitation of calcium current by depolarizing prepulses has been observed in many cells including cardiac muscle. The mechanism underlying prepulse facilitation is controversial with respect to the requirements of channel subunits and cAMP kinase. We found that coexpression of the cardiac alpha1C-a subunit with the cardiac beta2a subunit significantly promotes the facilitation of I(Ba) by strong depolarizing prepulses. The magnitude of I(Ba) facilitation depended on the voltage potential of… CONTINUE READING

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