The role of substance P in stress and anxiety responses

@article{Ebner2006TheRO,
  title={The role of substance P in stress and anxiety responses},
  author={K. Ebner and N. Singewald},
  journal={Amino Acids},
  year={2006},
  volume={31},
  pages={251-272}
}
Summary.Substance P (SP) is one of the most abundant peptides in the central nervous system and has been implicated in a variety of physiological and pathophysiological processes including stress regulation, as well as affective and anxiety-related behaviour. Consistent with these functions, SP and its preferred neurokinin 1 (NK1) receptor has been found within brain areas known to be involved in the regulation of stress and anxiety responses. Aversive and stressful stimuli have been shown… Expand
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References

SHOWING 1-10 OF 259 REFERENCES
Substance P Receptor Antagonists in Psychiatry
Substance P in the medial amygdala: Emotional stress-sensitive release and modulation of anxiety-related behavior in rats
Do substance P and the NK1 receptor have a role in depression and anxiety?
  • S. McLean
  • Medicine
  • Current pharmaceutical design
  • 2005
Effects of whole-body vibration stress on substance P- and neurotensin-like immunoreactivity in the rat brain.
Antidepressant properties of substance P antagonists: relationship to monoaminergic mechanisms?
  • A. Adell
  • Chemistry, Medicine
  • Current drug targets. CNS and neurological disorders
  • 2004
Effect of tachykinin receptor inhibition in the brain on cardiovascular and behavioral responses to stress.
Behavioral and physiologic effects of genetic or pharmacologic inactivation of the substance P receptor (NK1).
Central tachykinins: mediators of defence reaction and stress reactions.
...
1
2
3
4
5
...