The role of substance P in microvascular responses in murine joint inflammation.

@article{Keeble2005TheRO,
  title={The role of substance P in microvascular responses in murine joint inflammation.},
  author={Julie Elizabeth Keeble and Mark Blades and Costantino Pitzalis and Fransisco Airton Castro da Rocha and Susan Diana Brain},
  journal={British journal of pharmacology},
  year={2005},
  volume={144 8},
  pages={1059-66}
}
1. Rheumatoid arthritis is a serious, inflammatory disease of the distal joints that has a possible neurogenic component underlying its pathology. 2. Substance P (SP), an endogenous neuropeptide that acts upon the neurokinin 1 (NK(1)) receptor, is released from sensory nerves and is involved in neurogenic inflammation. 3. In this study, we have developed novel techniques to determine the contribution of SP to microvascular responses in a model of complete Freund's adjuvant (CFA)-induced… CONTINUE READING
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