The role of substance P in inflammatory disease

@article{Oconnor2004TheRO,
  title={The role of substance P in inflammatory disease},
  author={T. O'connor and J. O'connell and Darren I. O'Brien and T. Goode and C. Bredin and F. Shanahan},
  journal={Journal of Cellular Physiology},
  year={2004},
  volume={201}
}
The diffuse neuroendocrine system consists of specialised endocrine cells and peptidergic nerves and is present in all organs of the body. Substance P (SP) is secreted by nerves and inflammatory cells such as macrophages, eosinophils, lymphocytes, and dendritic cells and acts by binding to the neurokinin‐1 receptor (NK‐1R). SP has proinflammatory effects in immune and epithelial cells and participates in inflammatory diseases of the respiratory, gastrointestinal, and musculoskeletal systems… Expand
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