The role of structural disorder in the rewiring of protein interactions through evolution.

@article{Mosca2012TheRO,
  title={The role of structural disorder in the rewiring of protein interactions through evolution.},
  author={Roberto Mosca and Roland A. Pache and Patrick Aloy},
  journal={Molecular & cellular proteomics : MCP},
  year={2012},
  volume={11 7},
  pages={
          M111.014969
        }
}
Structurally disordered regions play a key role in protein-protein interaction networks and the evolution of highly connected proteins, enabling the molecular mechanisms for multiple binding. However, the role of protein disorder in the evolution of interaction networks has only been investigated through the analysis of individual proteins, making it impossible to distinguish its specific impact in the (re)shaping of their interaction environments. Now, the availability of large interactomes… CONTINUE READING
BETA

Similar Papers

Figures, Tables, and Topics from this paper.

Explore Further: Topics Discussed in This Paper

Citations

Publications citing this paper.
SHOWING 1-10 OF 30 CITATIONS

A million peptide motifs for the molecular biologist.

VIEW 4 EXCERPTS
CITES BACKGROUND
HIGHLY INFLUENCED

Proteomics in evolutionary ecology.

  • Journal of proteomics
  • 2016
VIEW 2 EXCERPTS
CITES BACKGROUND

References

Publications referenced by this paper.
SHOWING 1-10 OF 59 REFERENCES

The Universal Protein Resource (UniProt) 2009

VIEW 8 EXCERPTS
HIGHLY INFLUENTIAL

Evolution and disorder.

  • Current opinion in structural biology
  • 2011
VIEW 1 EXCERPT

Protein disorder--a breakthrough invention of evolution?

  • Current opinion in structural biology
  • 2011
VIEW 1 EXCERPT

Unstructural biology coming of age.

  • Current opinion in structural biology
  • 2011