The role of structural disorder in the rewiring of protein interactions through evolution.

@article{Mosca2012TheRO,
  title={The role of structural disorder in the rewiring of protein interactions through evolution.},
  author={Roberto Mosca and Roland A. Pache and Patrick Aloy},
  journal={Molecular & cellular proteomics : MCP},
  year={2012},
  volume={11 7},
  pages={M111.014969}
}
Structurally disordered regions play a key role in protein-protein interaction networks and the evolution of highly connected proteins, enabling the molecular mechanisms for multiple binding. However, the role of protein disorder in the evolution of interaction networks has only been investigated through the analysis of individual proteins, making it impossible to distinguish its specific impact in the (re)shaping of their interaction environments. Now, the availability of large interactomes… CONTINUE READING