The role of stroma in prostatic carcinogenesis

  title={The role of stroma in prostatic carcinogenesis},
  author={Gary D. Grossfeld and Simon W Hayward and Thea D. Tlsty and Gerald R. Cunha},
Most human prostate tumors are adenocarcinomas which arise from the epithelial cells that line the glands and ducts of the prostate. Consequently, the malignant epithelial cell, or more specifically genetic damage suffered by that malignant epithelial cell, has been the major focus of prostate cancer research to date. There is, however, increasing evidence to suggest that alterations in the stromal microenvironment associated with a malignant epithelium may be necessary for progression of… CONTINUE READING


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