The role of stress-activated protein kinase signaling in renal pathophysiology.

@article{Ma2009TheRO,
  title={The role of stress-activated protein kinase signaling in renal pathophysiology.},
  author={Frank Y. Ma and J Liu and David J Nikolic-Paterson},
  journal={Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas},
  year={2009},
  volume={42 1},
  pages={29-37}
}
Two major stress-activated protein kinases are the p38 mitogen-activated protein kinase (MAPK) and the c-Jun amino terminal kinase (JNK). p38 and JNK are widely expressed in different cell types in various tissues and can be activated by a diverse range of stimuli. Signaling through p38 and JNK is critical for embryonic development. In adult kidney, p38 and JNK signaling is evident in a restricted pattern suggesting a normal physiological role. Marked activation of both p38 and JNK pathways… CONTINUE READING