The role of steroid hormones in the NF1 phenotype: focus on pregnancy.

Abstract

The Neurofibromatosis Type 1 (NF1) gene functions as a tumor suppressor gene. Loss of its protein, neurofibromin, in the autosomal dominant disorder NF1 is associated with peripheral nervous system tumors, particularly neurofibromas, benign lesions in which the major cell type is the Schwann Cell (SC). Benign and malignant human tumors found in NF1 patients… (More)
DOI: 10.1002/ajmg.a.32301

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