The role of splicing factors in deregulation of alternative splicing during oncogenesis and tumor progression.

@article{Shilo2015TheRO,
  title={The role of splicing factors in deregulation of alternative splicing during oncogenesis and tumor progression.},
  author={A. V. Shilo and Zahava Siegfried and Rotem Karni},
  journal={Molecular & cellular oncology},
  year={2015},
  volume={2 1},
  pages={e970955}
}
In past decades, cancer research has focused on genetic alterations that are detected in malignant tissues and contribute to the initiation and progression of cancer. These changes include mutations, copy number variations, and translocations. However, it is becoming increasingly clear that epigenetic changes, including alternative splicing, play a major role in cancer development and progression. There are relatively few studies on the contribution of alternative splicing and the splicing… CONTINUE READING