The role of sphingolipids in the control of skeletal muscle function: a review

@article{Sabbadini1999TheRO,
  title={The role of sphingolipids in the control of skeletal muscle function: a review},
  author={Roger Allen Sabbadini and Daniela Danieli-Betto and Romeo Betto},
  journal={The Italian Journal of Neurological Sciences},
  year={1999},
  volume={20},
  pages={423-430}
}
In this review, potential roles for the endogenous sphingolipid, shingosine, and its derivatives are described for muscle cells. Sphingosine modulates the function of important calcium channels in muscle, including the ryanodine receptor (RyR) calcium release channel of the sarcoplasmic reticulum (SR). Sphingosine blocks calcium release through the SR ryanodine receptor and reduces the activity of single skeletal muscle RyR channels reconstituted into planar lipid bilayers. Sphingosine-blocked… CONTINUE READING

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References

Publications referenced by this paper.
Showing 1-10 of 86 references

Sphingosylphosphorylcholine modulates the ryanodine receptor Ca2+ release channel of cardiac sarcoplasmic reticulum membranes

R Betto, A Teresi, +7 authors PT Palade
Biochem J • 1997
View 6 Excerpts
Highly Influenced

Modulation of cardiac SR ryanodine receptor by endogenous sphingosine

C Dettbarn, R Betto, +3 authors RA Sabbadini
J Mol Cell Biol • 1994
View 6 Excerpts
Highly Influenced

Comparative analysis of three murine G-protein coupled receptors activated by sphingosine-1-phosphate

G Zhang, JJA Cantos, JA Weiner, N Fukushima, J Chun
Gene • 1999
View 1 Excerpt

L-carnitine prevents doxorubicin-induced apoptosis of cardiac myocytes: role of inhibition of ceramide generation.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology • 1999
View 3 Excerpts

Diversity of cellular receptors and functions for the lysophospholipid growth factors lysophosphatidic acid and sphingosine 1-phosphate.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology • 1998
View 1 Excerpt

MKK6 inhibits myocardial cell apoptosis via a p38 MAP kinase-dependent pathway

D Zechner, R Craig, +3 authors CC Glembotski
J Biol Chem • 1998
View 1 Excerpt

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