The role of spermidine/spermine N1-acetyltransferase in endotoxin-induced acute kidney injury.


The expression of catabolic enzymes spermidine/spermine N(1)-acetyltransferase (SSAT) and spermine oxidase (SMO) increases after ischemic reperfusion injury. We hypothesized that polyamine catabolism is upregulated and that this increase in catabolic response contributes to tissue damage in endotoxin-induced acute kidney injury (AKI). SSAT mRNA expression… (More)
DOI: 10.1152/ajpcell.00512.2009


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