The role of specific early trauma in adult depression: A meta-analysis of published literature. Childhood trauma and adult depression

  title={The role of specific early trauma in adult depression: A meta-analysis of published literature. Childhood trauma and adult depression},
  author={Laura Mandelli and Cristina Petrelli and Alessandro Serretti},
  journal={European Psychiatry},
  pages={665 - 680}

Bullying, Psychological, and Physical Trauma During Early Life Increase Risk of Major Depressive Disorder in Adulthood: A Nationwide Community Sample of Korean Adults

Bullying trauma during early life represents a risk factor for MDD, especially in individuals exposed to multiple traumas in early life, especially after adjusting for age, gender, marriage, job, and education years.

Examining the Associations Between Childhood Trauma, Resilience, and Depression: A Multivariate Meta-Analysis

The pooled correlations indicate that trauma, resilience, and depression are significantly associated and Resilience significantly mediated the association between trauma and depression.

Early Maladaptive Schemas and Depression in Adulthood: A Systematic Review and Meta-Analysis.

The evidence suggests that individuals who feel like they do not belong, or that they are flawed, bad, or unlovable, report higher levels of depression, and focusing treatment on the Social Isolation and Defectiveness/Shame EMS may aid in relieving depressive symptoms.

Influence of childhood trauma on depression in the INDDEP study

Clinicians should take the high probability of childhood trauma in depressive patients and the consequent risk of more severe symptoms into account when taking a history and consider adjusting treatment, even if the present data showed that patients generally benefitted from therapy.

Childhood Trauma and Treatment Implications in Major Depressive Disorder in South Korea: Comparison with Medical Outpatients and Two-Year Follow-Up

There is a growing body of literature proposing an etiological association between experiences of previous trauma, particularly ones of an early interpersonal nature, and later development of major

Adverse childhood experiences and trajectories of psychological distress in adulthood: an analysis of the 1958 British birth cohort

If the associations between ACEs and trajectories of distress are causal, this emphasises the need to act early to prevent psychopathology across the adult life course.

The impact of maternal depressive symptoms and traumatic events on early childhood mental health in conflict-affected Timor-Leste

Maternal depressive symptoms are longitudinally associated with child mental health, and traumatic events play a role, suggesting the need for skilled assessment for depression, trauma-informed maternity care and parenting support in a post-conflict country such as Timor-Leste.



The importance of childhood trauma and childhood life events for chronicity of depression in adults.

The results suggest that multiple childhood traumas can be seen as an independent determinant of chronicity of depression, and it is therefore important to detect the presence of childhood trauma.

Adult mood disorders and childhood psychological trauma.

The findings document an association between violence during childhood and adult mood disorders, especially for manic patients, in a developing country.

Adverse childhood experiences and the risk of depressive disorders in adulthood.

Relationship of childhood maltreatment to the onset and course of major depression in adulthood

To the extent that these data are valid, they suggest that childhood maltreatment may influence the onset, course, and comorbid character of major depression.

Protective effect of CRHR1 gene variants on the development of adult depression following childhood maltreatment: replication and extension.

A haplotype in CRHR1 has been suggested to exert a protective effect against adult depression among research participants who reported maltreatment on the CTQ, a measure that elicits emotional memories, and this suggests the hypothesis thatCRHR1's protective effect may relate to its function in the consolidation of memories of emotionally arousing experiences.

Childhood sexual abuse, stressful life events and risk for major depression in women

As documented with physiological responses to a standardized laboratory stressor, CSA increases stress sensitivity in women in a more naturalistic setting and a ‘dose–response’ relationship between severity of CSA and sensitivity to SLEs was clearer in Those with low to average levels of N than in those with high Levels of N.

The role of childhood trauma in the neurobiology of mood and anxiety disorders: preclinical and clinical studies

Predicting depression in women: the role of past and present vulnerability

An aetiological model of depression outlined in earlier research was confined with a new factor of teenage depression shown to increase risk of onset, and a relationship between childhood neglect/abuse and onset was entirely accounted for by such early depression.

Sexual abuse and lifetime diagnosis of psychiatric disorders: systematic review and meta-analysis.

A history of sexual abuse is associated with an increased risk of a lifetime diagnosis of multiple psychiatric disorders and associations between sexual abuse and depression, eating disorders, and posttraumatic stress disorder were strengthened by a history of rape.