The role of specific antibody in alternative complement pathway- mediated opsonophagocytosis of type III, group B Streptococcus

@article{Edwards1980TheRO,
  title={The role of specific antibody in alternative complement pathway- mediated opsonophagocytosis of type III, group B Streptococcus},
  author={Morven S. Edwards and Anne Nicholson-Weller and Carol J. Baker and Dennis L Kasper},
  journal={The Journal of Experimental Medicine},
  year={1980},
  volume={151},
  pages={1275 - 1287}
}
The native capsular polysaccharide antigen of type III, group B Streptococcus contains a terminal sialic acid residue on each repeating unit that masks all end-group galactopyranose residues and prevents alternative pathway complement activation by adult human sera in the absence of type-specific antibody. The critical role of the sialic acid residues in allowing the organism to evade activating the alternative complement pathway was shown when neuraminidase treatment of the organism converted… CONTINUE READING
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