The role of somatic mutation in the pathogenic anti-DNA response.

  title={The role of somatic mutation in the pathogenic anti-DNA response.},
  author={Betty Diamond and Joachim Katz and Elahna Paul and Cynthia Aranow and Daniel Lawrence Lustgarten and Matthew D. Scharff},
  journal={Annual review of immunology},
Anti-DNA antibodies represent a significant autospecificity in systemic lupus erythematosus because they are essentially diagnostic of the disease and they contribute to renal pathology. The molecular genetic characterization of these antibodies from both lupus-prone mice and humans with lupus has shown them to be somatically mutated. In many cases the nature of the mutations suggests that DNA or some structurally homologous molecule is driving the response. In other cases the high replacement… CONTINUE READING


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