The role of snRNAs in spliceosomal catalysis.

  title={The role of snRNAs in spliceosomal catalysis.},
  author={Saba Valadkhan},
  journal={Progress in molecular biology and translational science},
The spliceosomes, large ribonucleoprotein (RNP) assemblies that remove the intervening sequences from pre-mRNAs, contain a large number of proteins and five small nuclear RNAs (snRNAs). One snRNA, U6, contains highly conserved sequences that are thought to be the functional counterparts of the RNA elements that form the active site of self-splicing group II intron ribozymes. An in vitro-assembled, protein-free complex of U6 with U2, the base-pairing partner in the spliceosomal catalytic core… CONTINUE READING