The role of small heterodimer partner in nonalcoholic fatty liver disease improvement after sleeve gastrectomy in mice.

@article{Myronovych2014TheRO,
  title={The role of small heterodimer partner in nonalcoholic fatty liver disease improvement after sleeve gastrectomy in mice.},
  author={Andriy Myronovych and Rosa-Maria Salazar-Gonzalez and Karen Koeninger Ryan and Lili Miles and Wujuan Zhang and Pinky Jha and Li Wang and Kenneth D R Setchell and Randy J Seeley and Rohit Kohli},
  journal={Obesity},
  year={2014},
  volume={22 11},
  pages={2301-11}
}
OBJECTIVE Bile acids (BA) are elevated after vertical sleeve gastrectomy (VSG) and farnesoid-X-receptor (FXR) is critical to the success of murine VSG. BA downregulate hepatic lipogenesis by activating the FXR-small heterodimer partner (SHP) pathway. The role of SHP in fatty liver disease improvement after VSG was tested. METHODS Wild type (WT), SHP liver transgenic (SHP-Tg), and SHP knockout (SHP-KO) high-fat diet (HFD) fed mice underwent either VSG or Sham surgery. Body weight, BA level and… CONTINUE READING