The role of single nucleotide polymorphisms of the ERCC1 and MMS19 genes in predicting platinum-sensitivity, progression-free and overall survival in advanced epithelial ovarian cancer.

@article{Moxley2013TheRO,
  title={The role of single nucleotide polymorphisms of the ERCC1 and MMS19 genes in predicting platinum-sensitivity, progression-free and overall survival in advanced epithelial ovarian cancer.},
  author={Katherine M. Moxley and Doris Mangiaracina Benbrook and Ilangovan Ramachandran and Rosemary Zuna and Deborah J Thompson and Micah McCumber and Prasanna Samuel Premkumar and Elangovan Thavathiru and Lucy Hines and Kathleen N. Moore},
  journal={Gynecologic oncology},
  year={2013},
  volume={130 2},
  pages={
          377-82
        }
}
OBJECTIVE This study aims to assess the role of polymorphisms in DNA repair genes, excision repair cross-complementation group 1 (ERCC1) and methyl-methanesulfonate sensitivity 19 (MMS19), in tumor response to platinum-based chemotherapy and survival in advanced epithelial ovarian cancer (EOC). METHODS Single nucleotide polymorphism (SNP) analysis was performed on the paraffin-embedded tumor tissue of women with advanced EOC, treated with platinum-based chemotherapy at the University of… CONTINUE READING
BETA

Similar Papers

References

Publications referenced by this paper.
SHOWING 1-10 OF 25 REFERENCES

Association of epidermal growth factor receptor activating mutations with low ERCC1 gene expression in non-small cell lung cancer.

  • Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer
  • 2010
VIEW 1 EXCERPT

Nucleotide excision repair pathway polymorphisms and pancreatic cancer risk: evidence for role of MMS19L.

  • Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology
  • 2009
VIEW 2 EXCERPTS

The relationship of platinum resistance and ERCC1 protein expression in epithelial ovarian cancer

KD Steffensen, M Waldstrom, A. Jakobsen
  • Int J Gynecol Cancer 2009;19:820–5
  • 2009
VIEW 1 EXCERPT

Prediction of response to chemotherapy by ERCC1 immunohistochemistry and ERCC1 polymorphism in ovarian cancer

KD Steffensen, M Waldstrom, U Jeppesen, I Brandslund, A. Jakobsen
  • Int J Gynecol Cancer
  • 2008
VIEW 1 EXCERPT