The role of signal transducers and activators of transcription in colon cancer.

@article{Klampfer2008TheRO,
  title={The role of signal transducers and activators of transcription in colon cancer.},
  author={Lidija Klampfer},
  journal={Frontiers in bioscience : a journal and virtual library},
  year={2008},
  volume={13},
  pages={2888-99}
}
  • Lidija Klampfer
  • Published 2008 in
    Frontiers in bioscience : a journal and virtual…
A family of latent cytoplasmic transcription factors, Signal Transducers and Activators of Transcription (STATs), convey signals from numerous cytokines and growth factors to the nucleus. Their expression and their activity have been shown to be perturbed in a variety of malignancies, including colorectal cancer. Among the STAT family members, oncogenic STAT3 has been shown to be constitutively activated or overexpressed in colon cancers. In contrast, the expression levels of STAT1 have been… CONTINUE READING