The role of shear stress in Blood-Brain Barrier endothelial physiology

@inproceedings{Cucullo2010TheRO,
  title={The role of shear stress in Blood-Brain Barrier endothelial physiology},
  author={Luca Cucullo and Mohammed Shadat Hossain and Vikram Puvenna and Nicola De Marchi and Damir Janigro},
  booktitle={BMC Neuroscience},
  year={2010}
}
One of the most important and often neglected physiological stimuli contributing to the differentiation of vascular endothelial cells (ECs) into a blood-brain barrier (BBB) phenotype is shear stress (SS). With the use of a well established humanized dynamic in vitro BBB model and cDNA microarrays, we have profiled the effect of SS in the induction/suppression of ECs genes and related functions. Specifically, we found a significant upregulation of tight and adherens junctions proteins and genes… CONTINUE READING
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