The role of serum response factor in hepatocellular carcinoma: implications for disease progression.

@article{Kwon2010TheRO,
  title={The role of serum response factor in hepatocellular carcinoma: implications for disease progression.},
  author={Chang Young Kwon and Kyung Ryoul Kim and Ha Na Choi and Myoung Ja Chung and Sang Jae Noh and Dae Ghon Kim and Myoung Jae Kang and Dong Geun Lee and Woo Sung Moon},
  journal={International journal of oncology},
  year={2010},
  volume={37 4},
  pages={
          837-44
        }
}
Serum response factor (SRF) regulates transcription of the immediate early genes and triggers proliferation, migration and differentiation in several types of cells. We examined the role of SRF in HCC by transfecting the SRF cDNA in HLE cells and the SRF anti-sense cDNA in sarcomatoid HCC cells. The overexpression of SRF in the HLE cells significantly increased the cell growth and proliferation. Overexpression of SRF increased actin polymerization of the HCC cells and induced morphologic… CONTINUE READING

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Serum response factor induces epithelial to mesenchymal transition with resistance to sorafenib in hepatocellular carcinoma.

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