The role of serotonin in adult hippocampal neurogenesis

  title={The role of serotonin in adult hippocampal neurogenesis},
  author={Natalia Alenina and Friederike Klempin},
  journal={Behavioural Brain Research},

Figures and Tables from this paper

Divergent Roles of Central Serotonin in Adult Hippocampal Neurogenesis
This paper reviews how changes in the central serotonergic system alter adult hippocampal neurogenesis in mice and focuses on data obtained from three categories of genetically engineered mouse models, providing unique insights to interpret the multifaceted roles of central 5-HT on adult hippocampusal Neurogenesis and its associated effects on depression.
Postnatal depletion of serotonin affects the morphology of neurons and the function of the hippocampus in male rats
It is found that critical developmental periods of serotonin depletion caused degeneration and swelling of neurons as well as significant neuronal loss in the hippocampal CA1, CA3, and dentate gyrus (DG) areas.
The Effect of Serotonin-Targeting Antidepressants on Neurogenesis and Neuronal Maturation of the Hippocampus Mediated via 5-HT1A and 5-HT4 Receptors
This review article will analyze studies demonstrating regulation of hippocampal functions and hippocampus-dependent behaviors by SSRIs and similar serotonergic agents to describe a potential new mechanism of action, in which 5-HT1A and5-HT4 receptor signaling modulates the function of the hippocampal DG at multiple levels, any of which could play a critical role in the antidepressant actions of 5- HT-enhancing drugs.
Neuronal and behavioral plasticity: the role of serotonin and BDNF systems tandem
5-HT–BDNF cross-talk is a potential target for the treatment of various neurological diseases and understanding the function of the members of BDNF system in response to challenges of the environment and the interaction with different 5-HT receptors in health and disease will one day lead to new classes of drugs.
Lack of Brain Serotonin Affects Feeding and Differentiation of Newborn Cells in the Adult Hypothalamus
It is concluded that precursor cells in the hypothalamus retain fate plasticity and respond to environmental challenges and could be exploited as therapeutic target in metabolic disease.
The role of adult neurogenesis in psychiatric and cognitive disorders
Neurogenesis in the adult hippocampus: history, regulation, and prospective roles
This article explores current advancements in adult hippocampal neurogenesis by presenting its history and evolution and studying its association with neural plasticity and describes the intracellular, extracellular, pathological, and environmental factors involved in its regulation.


Oppositional Effects of Serotonin Receptors 5-HT1a, 2, and 2c in the Regulation of Adult Hippocampal Neurogenesis
The selective serotonin reuptake inhibitor fluoxetine, which has no acute effect on precursor cell proliferation, causes the well-described increase in net neurogenesis upon prolonged treatment partly by promoting the survival and maturation of new postmitotic neurons.
Lack of brain serotonin affects postnatal development and serotonergic neuronal circuitry formation
Findings reveal that alterations of serotonin levels during CNS development affect the proper wiring of the brain that may produce long-lasting changes leading to neurodevelopmental disorders.
Hippocampal neurogenesis: Opposing effects of stress and antidepressant treatment
The literature that has lead to a neurogenic hypothesis of depression and antidepressant action, as well as the molecular and cellular mechanisms that underlie the regulation of adult neurogenesis by stress and antidepressant treatment are discussed.
Reversal of hippocampal neuronal maturation by serotonergic antidepressants
The results suggest that serotonergic antidepressants can reverse the established state of neuronal maturation in the adult hippocampus, and up-regulation of 5-HT4 receptor-mediated signaling may play a critical role in this distinct action of antidepressants.
BDNF overexpression in mouse hippocampal astrocytes promotes local neurogenesis and elicits anxiolytic-like activities
The results indicate that BDNF overexpression in hippocampal astrocytes produced anxiolytic-/antidepressant-like activity in the novelty suppressed feeding in relation with the stimulation of hippocampal neurogenesis whereas it did not potentiate the effects of the SSRI fluoxetine on these parameters.
The effects of congenital brain serotonin deficiency on responses to chronic fluoxetine
It is indicated that brain 5-HT deficiency reduces the efficacy of FLX and that supplementation with 5-hydroxytryptophan can restore some antidepressant-like responses in the context of 5- HT deficiency.
Paradoxical increase in survival of newborn neurons in the dentate gyrus of mice with constitutive depletion of serotonin
The results indicate that constitutive 5‐ HT depletion does not alter the proliferation of neural precursors in the DG but promotes the survival of newborn cells, an effect which involves activation of postsynaptic 5‐HT1A receptors.
Influence of brain-derived neurotrophic factor (BDNF) on serotonin neurotransmission in the hippocampus of adult rodents.
Adult hippocampal neurogenesis in depression
The functional differentiation of the hippocampus along the septo-temporal axis is revisited and it is suggested that neurogenesis in the ventral dentate gyrus may be preferentially involved in regulation of emotion.