The role of selfish genetic elements in eukaryotic evolution

@article{Hurst2001TheRO,
  title={The role of selfish genetic elements in eukaryotic evolution},
  author={Gregory D. D. Hurst and John H. Werren},
  journal={Nature Reviews Genetics},
  year={2001},
  volume={2},
  pages={597-606}
}
'Selfish genetic elements', such as transposons, homing endonucleases, meiotic drive chromosomes and heritable microorganisms, are common features of eukaryotes. However, their importance in the evolution of eukaryotic genomes is still controversial. In this review, we discuss these diverse elements and their potential importance in the evolution of genetic systems, adaptation, and the extinction and birth of species. 

Figures, Tables, and Topics from this paper

Impact of transposable elements on the evolution of mammalian gene regulation
TLDR
The impact TEs have on the evolution of gene regulation and gene function with an emphasis on humans is reviewed and the mechanisms resulting in genomic change are reviewed. Expand
Origins of eukaryotic sexual reproduction.
TLDR
Using the perspectives of molecular genetics and cell biology, documented and hypothetical scenarios for the instantiation and evolution of meiosis, fertilization, sex determination, uniparental inheritance of organelle genomes, and speciation are considered. Expand
Host-transposon interactions: conflict, cooperation, and cooption.
TLDR
It is argued that the evolutionary success of TEs cannot be explained solely by evasion from host control mechanisms, rather, some TEs have evolved commensal and even mutualistic strategies that mitigate the cost of their propagation. Expand
Composition and evolutionary importance of transposable elements in humans and primates
TLDR
This review discussed about the impact of transposable element, its role in the genome of human and primates and how TE distribution is differ from them, and described how TEs contributed on primate evolution by its unique role. Expand
Transposons as Natural and Experimental Mutagens
Transposons are sequences of deoxyribonucleic acid (DNA) that have the ability to move from one genome location to another causing deleterious mutations and chromosome rearrangements. These elements,Expand
Degeneration and domestication of a selfish gene in yeast: molecular evolution versus site-directed mutagenesis.
TLDR
VDE is a homing endonuclease gene in yeasts with an unusual evolutionary history including horizontal transmission, degeneration, and domestication into the mating-type switching locus HO, and its effects on its molecular evolution are investigated. Expand
Gene drive systems for insect disease vectors
TLDR
The potential of natural gene drive systems for spreading genes that can block the transmission of insect-borne pathogens are explored and the artificial constructs that could be envisaged for this purpose are discussed. Expand
Genetic and evolutionary analysis of diversification and reproductive isolation in yeast
TLDR
The thesis investigates how tiny genetic differences occurring in individuals accumulate and produce discontinuous groups. Expand
Paramutation and related phenomena in diverse species
TLDR
Roles for the respective nuclear systems that regulate transposons via small RNA molecules both for paramutation and for defining transgenerational inheritance are highlighted. Expand
Properties of mobile elements of genomes and their application in biotechnology
Transposons (transposable elements, TEs) are DNAfragments capable of transposition, i.e., changing theirlocation in the genome. They can spread inside singlegenomes, between genomes within aExpand
...
1
2
3
4
5
...

References

SHOWING 1-10 OF 117 REFERENCES
Selfish genes, the phenotype paradigm and genome evolution
Natural selection operating within genomes will inevitably result in the appearance of DNAs with no phenotypic expression whose only ‘function’ is survival within genomes. Prokaryotic transposableExpand
PERSPECTIVE: TRANSPOSABLE ELEMENTS, PARASITIC DNA, AND GENOME EVOLUTION
TLDR
It is argued that easy popular appellations such as “selfish DNA’ and “junk DNA” may be either inaccurate or misleading and that a more enlightened view of the transposable element-host relationship encompasses a continuum from extreme parasitism to mutualism. Expand
The evolutionary dynamics of repetitive DNA in eukaryotes
TLDR
Features of the organization of repetitive sequences in eukaryotic genomes, and their distribution in natural populations, reflect the evolutionary forces acting on selfish DNA. Expand
Selfish genetic elements and speciation
TLDR
It is concluded that although some of the case studies are tantalizing, particularly those associated with Wolbachia, the role of selfish genetic elements in speciation remains unproven. Expand
Selfish DNA: a sexually-transmitted nuclear parasite.
A quantitative population genetics model for the evolution of transposable genetic elements is developed. This model shows that "selfish" DNA sequences do not have to be selectively neutral at theExpand
Selfish genetic elements.
TLDR
The purpose of this report is to indicate how widespread such selfish genetic elements are, and to review the main evolutionary and population genetic questions relating to them. Expand
On the theory of speciation induced by transposable elements.
TLDR
A simple methematical model describes the invasion of panmictic, sexually reproducing populations by a newly introduced transposon and describes the kinetics with which such an invasion will occur. Expand
Genetic scrambling as a defence against meiotic drive.
TLDR
It is shown that genes increasing crossing over are favoured, in the process of breaking up drive systems and reducing the fitness loss to organisms. Expand
Selfish behavior of restriction-modification systems
TLDR
Plasmids carrying gene pairs encoding type II DNA restriction endonucleases and their cognate modification enzymes were shown to have increased stability in Escherichia coli, showing the capacity of these genes to act as a selfish symbiont to contribute to the evolution of restriction-modification gene pairs. Expand
Genome reshuffling of the copia element in an inbred line of Drosophila melanogaster
TLDR
It is concluded that the transpositions of the copia element in this line occurred rapidly in a few generations, which may account for the instability sometimes observed in inbred lines and may be important in creating genetic variability in highly homozygous populations. Expand
...
1
2
3
4
5
...