The role of self-association in Fin1 function on the mitotic spindle.

@article{Woodbury2007TheRO,
  title={The role of self-association in Fin1 function on the mitotic spindle.},
  author={Erika L. Woodbury and David O. Morgan},
  journal={The Journal of biological chemistry},
  year={2007},
  volume={282 44},
  pages={32138-43}
}
Stabilization of spindle microtubules during anaphase is essential for proper chromosome segregation. Fin1 is a budding yeast protein that localizes to the poles and microtubules of the spindle during anaphase and contributes to spindle stability. The N-terminal half of Fin1 is phosphorylated at multiple sites by the cyclin-dependent kinase Clb5-Cdk1, and dephosphorylation in anaphase triggers its localization to the spindle. The C-terminal half of Fin1 contains coiled-coil motifs that are… CONTINUE READING