The role of selectins in inflammation and disease.

@article{Ley2003TheRO,
  title={The role of selectins in inflammation and disease.},
  author={Klaus Ley},
  journal={Trends in molecular medicine},
  year={2003},
  volume={9 6},
  pages={
          263-8
        }
}
Selectins are carbohydrate-binding molecules that bind to fucosylated and sialylated glycoprotein ligands, and are found on endothelial cells, leukocytes and platelets. They are involved in trafficking of cells of the innate immune system, T lymphocytes and platelets. An absence of selectins or selectin ligands has serious consequences in mice or humans, leading to recurrent bacterial infections and persistent disease. Selectins are involved in constitutive lymphocyte homing, and in chronic and… CONTINUE READING

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