The role of scaffold proteins in MEK/ERK signalling.

  title={The role of scaffold proteins in MEK/ERK signalling.},
  author={David B Sacks},
  journal={Biochemical Society transactions},
  volume={34 Pt 5},
Signal transduction networks allow cells to recognize and respond to changes in the extracellular environment. All eukaryotic cells have MAPK (mitogen-activated protein kinase) pathways that participate in diverse cellular functions, including differentiation, survival, transformation and movement. Five distinct groups of MAPKs have been characterized in mammals, the most extensively studied of which is the Ras/Raf/MEK [MAPK/ERK (extracellular-signal-regulated kinase) kinase]/ERK cascade… CONTINUE READING