The role of ribosome recycling factor in dissociation of 70S ribosomes into subunits.

@article{Hirokawa2005TheRO,
  title={The role of ribosome recycling factor in dissociation of 70S ribosomes into subunits.},
  author={Go Hirokawa and Romana M. Nijman and Vishnu S Raj and H. Kaji and Kazuei Igarashi and Akira Kaji},
  journal={RNA},
  year={2005},
  volume={11 8},
  pages={1317-28}
}
Protein synthesis is initiated on ribosomal subunits. However, it is not known how 70S ribosomes are dissociated into small and large subunits. Here we show that 70S ribosomes, as well as the model post-termination complexes, are dissociated into stable subunits by cooperative action of three translation factors: ribosome recycling factor (RRF), elongation factor G (EF-G), and initiation factor 3 (IF3). The subunit dissociation is stable enough to be detected by conventional sucrose density… CONTINUE READING

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