The role of retinoic acid in embryonic and post-embryonic development

@article{Maden2000TheRO,
  title={The role of retinoic acid in embryonic and post-embryonic development},
  author={Malcolm Maden},
  journal={Proceedings of the Nutrition Society},
  year={2000},
  volume={59},
  pages={65 - 73}
}
  • M. Maden
  • Published 1 February 2000
  • Biology
  • Proceedings of the Nutrition Society
Retinoic acid (RA) is the bioactive metabolite of vitamin A (retinol) which acts on cells to establish or change the pattern of gene activity. Retinol is converted to RA by the action of two types of enzyme, retinol dehydrogenases and retinal dehydrogenases. In the nucleus RA acts as a ligand to activate two families of transcription factors, the RA receptors (RAR) and the retinoid X receptors (RXR) which heterodimerize and bind to the upstream sequences of RA-responsive genes. Thus, in… 

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  • Biology
    Developmental dynamics : an official publication of the American Association of Anatomists
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It is suggested that upregulation of ADH‐IV and ALDH‐I gene expression in primitive streak mesoderm may lead to retinoic acid synthesis and initiation of retinoid signaling during mouse embryogenesis.
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