The role of retinoic acid in embryonic and post-embryonic development

@article{Maden2000TheRO,
  title={The role of retinoic acid in embryonic and post-embryonic development},
  author={M. Maden},
  journal={Proceedings of the Nutrition Society},
  year={2000},
  volume={59},
  pages={65 - 73}
}
  • M. Maden
  • Published 2000
  • Biology, Medicine
  • Proceedings of the Nutrition Society
Retinoic acid (RA) is the bioactive metabolite of vitamin A (retinol) which acts on cells to establish or change the pattern of gene activity. Retinol is converted to RA by the action of two types of enzyme, retinol dehydrogenases and retinal dehydrogenases. In the nucleus RA acts as a ligand to activate two families of transcription factors, the RA receptors (RAR) and the retinoid X receptors (RXR) which heterodimerize and bind to the upstream sequences of RA-responsive genes. Thus, in… Expand
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TLDR
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TLDR
P450RAI represents the first enzymatic component of RA metabolism to be isolated and characterized at the molecular level and provides key insight into regulation of retinoid homeostasis. Expand
Identification of a mechanism to localize generation of retinoic acid in rat embryos
TLDR
First evidence of a tissue-specific mechanism for generation of RA from its precursor retinol in the developing embryo is shown, suggesting that coordinate functioning of these proteins is responsible for cellular uptake of circulating Retinol and its metabolism to RA. Expand
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TLDR
Interestingly, a dose-dependent depression in retinol levels was observed after RA treatment both in maternal plasma as well as the embryo, and studies are in progress to trace the intracellular disposition of bothretinol and RA as wellAs any further active metabolite of RA in the limb buds and other embryonic tissues. Expand
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TLDR
The results indicate that the effects on growth inhibition and RARbeta transactivation of P19 EC cells are mediated directly by RA, while the onset of neuronal differentiation and the subsequent expression of neuronal markers is mediated by hCYP26 via the conversion of RA to its hydroxylated products. Expand
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TLDR
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TLDR
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TLDR
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TLDR
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TLDR
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