The role of resistance in HCV treatment.

@article{Vermehren2012TheRO,
  title={The role of resistance in HCV treatment.},
  author={Johannes Vermehren and Christoph Sarrazin},
  journal={Best practice & research. Clinical gastroenterology},
  year={2012},
  volume={26 4},
  pages={487-503}
}
The recent development of small molecule compounds that directly inhibit the viral life cycle represents a major milestone for the treatment of chronic hepatitis C virus (HCV) infection. These new drugs that are collectively termed direct-acting antivirals (DAA) include a range of inhibitors of the non-structural (NS) 3/4A protease, NS5B polymerase and NS5A protein. Two NS3/4A protease inhibitors (boceprevir and telaprevir) in combination with pegylated interferon and ribavirin have now been… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 59 extracted citations

Similar Papers

Loading similar papers…