The role of renal sympathetic nervous system in the pathogenesis of ischemic acute renal failure

@article{Fujii2003TheRO,
  title={The role of renal sympathetic nervous system in the pathogenesis of ischemic acute renal failure},
  author={Toshihide Fujii and Hayato Kurata and Masanori Takaoka and Tomoko Muraoka and Yoshihide Fujisawa and Takatomi Shokoji and Akira Nishiyama and Youichi Abe and Yasuo Matsumura},
  journal={European journal of pharmacology},
  year={2003},
  volume={481 2-3},
  pages={
          241-8
        }
}
We investigated the role of renal sympathetic nervous system in the progression of ischemia/reperfusion-induced acute renal failure in rats. Acute renal failure was induced by clamping the left renal artery and vein for 45 min followed by reperfusion, 2 weeks after the contralateral nephrectomy. Renal venous plasma norepinephrine concentrations markedly and significantly increased immediately after reperfusion, thereafter, the increased level declined but remained higher even at 24 h after… CONTINUE READING
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