The role of regulatory T cells in multiple sclerosis

  title={The role of regulatory T cells in multiple sclerosis},
  author={Alla L. Zozulya and Heinz Wiendl},
  journal={Nature Clinical Practice Neurology},
The dysregulation of inflammatory responses and of immune self-tolerance is considered to be a key element in the autoreactive immune response in multiple sclerosis (MS). Regulatory T (TREG) cells have emerged as crucial players in the pathogenetic scenario of CNS autoimmune inflammation. Targeted deletion of TREG cells causes spontaneous autoimmune disease in mice, whereas augmentation of TREG-cell function can prevent the development of or alleviate variants of experimental autoimmune… CONTINUE READING
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