The role of regulated protein degradation in auxin response

  title={The role of regulated protein degradation in auxin response},
  author={Sunethra Dharmasiri and Mark Estelle},
  journal={Plant Molecular Biology},
Auxin-regulated gene expression is mediated by two families of transcription factors. The ARF proteins bind to a conserved DNA sequence called the AuxRE and activate transcription. The Aux/IAA proteins repress ARF function, presumably by forming dimers with ARF proteins. Recent genetic studies in Arabidopsis indicate that auxin regulates this system by promoting the ubiquitin-mediated degradation of the Aux/IAA proteins, thus permitting ARF function. Mutations in components of SCFTIR1, a… CONTINUE READING

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