The role of recombinant stem cell factor in early B cell development. Synergistic interaction with IL-7.

@article{Mcniece1991TheRO,
  title={The role of recombinant stem cell factor in early B cell development. Synergistic interaction with IL-7.},
  author={I K Mcniece and Keith E. Langley and Krisztina M. Zsebo},
  journal={Journal of immunology},
  year={1991},
  volume={146 11},
  pages={3785-90}
}
The cDNA for stem cell factor was recently isolated from Buffalo rat liver cells (BRL-3A) and recombinant rat stem cell factor produced from Escherichia coli (rrSCF164). rrSCF164 synergizes with rhIL-7 to stimulate pre-B clonal growth in agar culture of mouse bone marrow cells, and in this study we have characterized the role of rrSCF164 in B cell development. The combination of rrSCF164 plus rhIL-7 stimulated increased colony numbers compared with the sum of colonies stimulated by rrSCF164 and… CONTINUE READING
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