The role of recombinant human bone morphogenetic protein-2 in PLGA capsules at an extraskeletal site of the rat.

@article{Isobe1999TheRO,
  title={The role of recombinant human bone morphogenetic protein-2 in PLGA capsules at an extraskeletal site of the rat.},
  author={Mitsuaki Isobe and Yasuharu Yamazaki and Masaji Mori and Kazuhiko Ishihara and Nobuo Nakabayashi and Teruo Amagasa},
  journal={Journal of biomedical materials research},
  year={1999},
  volume={45 1},
  pages={36-41}
}
Bone morphogenetic protein-2 (BMP-2) is a member of the transforming growth factor-beta (TGF-beta) superfamily and has strong bone-inductive activity in vivo. To examine the role of BMP-2 in an extraskeletal site of rat using a controlled release system of peptides, we encapsulated the recombinant human BMP-2 (rhBMP-2) with poly(DL-lactide-co-glycolide) (PLGA) and implanted the rhBMP-2/PLGA capsules in the subcutaneous area of rats. Upon histochemical examination, it was found that bone… CONTINUE READING
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